The role and the signal pathways of Yes-associated protein 2 in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a heterogeneous myocardial disease characterized by hypertrophy, mechanical and electrical activity obstacles. This study aimed to explore the relationship between YAP2 (Yes-associated protein 2) HCM clarify signaling path about pathogenesis of HCM. Our confirms that can promote cell hypertrophy at molecular level (myocardial lineage H9C2), organ (clinical specimens human HCM), an animal model (a mouse with cardiac-specific transgenic knockout YAP2). The detailed mechanisms linking cardiomyocyte were investigated. proved YAP2, as final reaction factor in Hippo pathways, influences Akt1 affect downstream genes, which participate formation promoting proliferation cardiac hypertrophy.